Hydro Air Research Italia

Pharmaceutical Application

Hydro Air Research Italia membrane systems are operating successfully in downstream processing including:

  • Harvest broth filtration
  • Extraction, purification and concentration of antibiotics, vitamins and organic acids.
  • Removal of pyrogen from biological liquids.
  • Cell harvesting using concentration and diafiltration methods.
  • Sterilization of nutrients liquids.
  • Cell debris removal.
  • Viruses and polysaccharides extraction purification processes.
  • Protein isolation and purification.
  • Extraction and purification of enzymes
  • Antibiotics recovery from organic solvents using solvent stable membranes.
  • Spent broth concentration and evaporation.

Proven experience of HARI includes the following:

  • Amikacin
  • Acarbose
  • Cephalosporin-C
  • Cephalexin
  • Clavulanic Acid
  • Daptomycin
  • Daunomycin
  • Enzymes
  • Erythromycin
  • Gibberellic Acid
  • Lysergic Acid
  • Rifamycin
  • Tetracyclin
  • Vancomycin
  • Vitamin C
  • Vitamin B12
  • 6-APA
  • 7-ACA

Hydro Air Research Italia membrane processes in separation and purification, compared with the conventional rotary precoat filters and centrifuges, are superior in terms of product yield, filtrate quality, operating costs and waste problems.

Hydro Air Research Italia system for antibiotic recovery includes the following steps:

  • Step 1: Fermentation broth clarification with ceramic membrane cross flow system ensures more of 95% activity recovery, filtration sparking quality, excellent protein removal and high permeate flux;
  • Step 2: Antibiotics Concentration with Naro System that guarantees active principle concentration while desalting, high yield and high concentration factor.


Hydro Air Research can also offer access to a range of new organic solvent Nanofiltration membranes suitable for use in nonaqueous applications. Typical applications for these membranes in the pharmaceutical and fine chemicals industries are solvent exchange, catalyst recycle, organics recovery and products purifications.

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Hydro Air Research Italia
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